Is Amitriptyline an SSRI or SNRI? A Pharmacological Comparison
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5 min read
Over the past few decades, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have largely replaced older medications like **amitriptyline** as a first-line treatment for depression due to a more favorable side-effect profile. While these newer classes have their own advantages, amitriptyline belongs to an earlier generation of antidepressants known as tricyclics (TCAs).
