Which is Better for Sleep, Amitriptyline or Mirtazapine?
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4 min read
According to a recent 2025 study in the *British Journal of General Practice*, low-dose mirtazapine showed a clinically relevant reduction in insomnia severity at 6 weeks, unlike low-dose amitriptyline, which produced a smaller, non-clinically relevant effect. This critical finding helps clarify which is better for sleep, amitriptyline or mirtazapine, in the short term, but a deeper dive into their pharmacology, side effects, and long-term use is necessary for a complete picture.
