Tag: Antihistamine withdrawal

In May 2025, the U.S. Food and Drug Administration (FDA) issued a warning that stopping long-term use of cetirizine (Zyrtec) or levocetirizine (Xyzal) may cause severe itching. This rare but documented phenomenon is the primary **rebound effect with Zyrtec**, affecting some individuals who discontinue the medication after daily use over several months or years.

In 2022, over 60 million packages of over-the-counter cetirizine products were sold in the U.S. [1.3.1, 1.7.1]. For some long-term users, stopping these medications raises the question: **how long do antihistamine withdrawal symptoms last?**

Although not officially classified with typical dependence potential, case reports confirm that stopping cyproheptadine can lead to significant withdrawal symptoms. The effects, which range from mild discomfort to severe agitation, are often linked to the drug's potent antiserotonergic properties. This article explores why withdrawal happens and how to manage it safely.

In 2021, over a quarter of U.S. adults reported having a seasonal allergy [1.6.1]. For many, this means daily antihistamines. But what happens when you stop taking Claritin? For most, it simply means a return of allergy symptoms [1.2.5].

While antihistamines are a common treatment for allergies, abruptly stopping some types can lead to temporary rebound effects. It is important to know what happens when you stop taking loratadine and how to distinguish between a return of allergies and discontinuation side effects.

In May 2025, the FDA required a warning for Zyrtec (cetirizine) regarding severe itching that can occur after stopping the medication, particularly with long-term use. Learning how to wean off Zyrtec properly is crucial to minimize uncomfortable withdrawal symptoms and manage your allergy needs effectively.