Tag: Aplastic anemia

Platify 50, a medication containing eltrombopag, is a thrombopoietin receptor agonist used to treat low platelet counts in conditions like chronic immune thrombocytopenia (ITP) and severe aplastic anemia. It is crucial for patients and caregivers to understand **what are the side effects of Platify 50** to manage them effectively, as this powerful medication can cause a range of adverse effects, both common and serious.

Chloramphenicol, sometimes known as Phenicol, is an antibiotic with a significant risk of severe adverse effects, with fatal aplastic anemia estimated to occur in up to 1 in 24,500 treatment courses. Therefore, it is critical to understand what are the side effects of Phenicol and why its use is strictly limited to serious, life-threatening infections when safer alternatives are not available or effective.

Within a year of its FDA approval in 1993, Felbatol (felbamate) was prescribed to over 126,000 patients [1.6.1]. The critical question for many is: Is Felbatol a controlled substance? The answer is no; it is not scheduled by the DEA [1.2.1].

First isolated from the bacterium *Streptomyces venezuelae* in 1947, chloramphenicol was the first synthetic broad-spectrum antibiotic ever produced in bulk [1.11.1, 1.11.2, 1.11.3]. So, how does chloramphenicol work simple? It functions by halting the production of essential proteins that bacteria need to grow and multiply [1.5.3].

Once hailed as a broad-spectrum antibiotic powerhouse in the late 1940s, chloramphenicol's widespread use was dramatically curtailed following the discovery of its severe, and often fatal, side effects. This led to stringent regulations and outright bans in many countries, shifting its status from a frontline treatment to a last-resort medication for life-threatening infections.

The most serious side effect of chloramphenicol is aplastic anemia, which is rare but sometimes fatal [1.4.6]. Due to its high toxicity, understanding **what are the contraindications of chloramphenicol?** is crucial before its use is considered [1.8.6].

Due to the high risk of fatal aplastic anemia, the FDA has severely restricted the use of the antibiotic chloramphenicol in the US. While not completely banned, its oral capsules were withdrawn from the market, and its use is limited to serious infections when no safer alternative is available.

First isolated in 1947, chloramphenicol was once celebrated as a powerful broad-spectrum antibiotic. However, a growing body of evidence linking the drug to rare but fatal side effects prompted severe regulatory restrictions, raising the question: Why is chloramphenicol banned in the USA?

Originally isolated in 1947 from the bacterium *Streptomyces venezuelae*, **what is chloramphenicol?** It is a powerful, broad-spectrum antibiotic whose systemic use is severely limited due to its potential for causing serious and sometimes fatal side effects, including aplastic anemia.

The most serious side effect of chloramphenicol is idiosyncratic aplastic anemia, a rare but often fatal condition that occurs in approximately 1 in 24,000 to 40,000 treatment courses [1.4.3, 1.2.4]. This article explores the significant human toxicities associated with this potent antibiotic.