Tag: Apoptosis

Overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of many cancers, making them an attractive target for novel therapies. The investigational anti-cancer agent Obatoclax is a BH3 mimetic designed to inhibit these pro-survival proteins. So, what is the mechanism of action of Obatoclax? Its effects are multifaceted and extend beyond simple apoptosis inhibition.

While the term 'ark drug' might be unfamiliar, it refers to several distinct pharmaceutical products and a naturally occurring biological protein. In one context, Ark is a brand of nonsteroidal anti-inflammatory drugs (NSAIDs) used to manage pain and inflammation. In another, ARC is a protein involved in the regulation of cell death. This article clarifies what is ark drug in its various forms.