Tag: Aqueous humor

Intraocular pressure (IOP) follows a natural circadian rhythm, often rising during nocturnal hours while the body is in a horizontal position. Because its primary mechanism of action is to suppress the production of aqueous humor, this rhythm, coupled with other physiological changes during sleep, is precisely **why is timolol not effective at night**.

With over 3 million Americans affected by glaucoma, understanding treatment is crucial [1.6.5]. So, what is the mechanism of action of Apraclonidine for glaucoma patients? This medication primarily acts as a selective alpha-2 adrenergic agonist to lower eye pressure [1.2.1].

While newer medications have become the standard for managing glaucoma, miotics still offer a powerful mechanism for lowering intraocular pressure, particularly in specific cases. Understanding **what is the mechanism of action of miotics in glaucoma** is key to appreciating their role in ophthalmology.