Tag: Autophagy

Overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of many cancers, making them an attractive target for novel therapies. The investigational anti-cancer agent Obatoclax is a BH3 mimetic designed to inhibit these pro-survival proteins. So, what is the mechanism of action of Obatoclax? Its effects are multifaceted and extend beyond simple apoptosis inhibition.

A computer modeling study identified withaferin A as a strong mimetic of rapamycin's gene expression patterns, yet no single supplement can perfectly replicate the potent, targeted effects of the prescription drug. For those interested in modulating the same longevity pathways, the question becomes: what is the closest supplement to rapamycin among the available natural options? This article explores the most promising candidates.

Over one million people are diagnosed with autoimmune diseases like lupus each year, and many are prescribed hydroxychloroquine. However, significant public interest and confusion arose regarding whether hydroxychloroquine is a chemo drug due to its exploration in cancer research, particularly during the COVID-19 pandemic. In fact, hydroxychloroquine is an antimalarial and immunomodulatory medication, not a traditional cytotoxic chemotherapy agent.