What is the mechanism of action of bardoxolone methyl?
•
3 min read
Bardoxolone methyl was a potent antioxidant and anti-inflammatory agent studied extensively in clinical trials for chronic kidney disease, notably increasing estimated glomerular filtration rate (eGFR) in patients with diabetic kidney disease. Its primary mechanism involves activating the Keap1/Nrf2 pathway, a critical cellular defense system against stress.
