Tag: Bempedoic acid

While statins are widely prescribed, a 2022 meta-analysis found the overall prevalence of statin intolerance is 9.1% [1.10.1]. For these individuals and others seeking options, knowing what can be done instead of statins is crucial for managing cholesterol and heart health.

In the United States, cardiovascular disease is a leading cause of death, with high cholesterol being a major risk factor. For individuals needing to manage their cholesterol levels, a common concern is determining **what is the safest drug to lower cholesterol** while minimizing side effects.

According to clinical studies, the incidence of gout or hyperuricemia (high uric acid) is not significantly increased by ezetimibe when used alone. It is a common misconception that ezetimibe causes gout, stemming from its inclusion in combination drugs that contain an ingredient known to raise uric acid levels.

Statins are the first-line therapy for most people with high cholesterol, but up to 30% of patients report intolerance, primarily due to muscle-related side effects. This raises a critical question: **Is Nexletol better than a statin** as an alternative treatment for lowering LDL cholesterol and reducing cardiovascular risk?

In clinical trials, diarrhea was one of the reasons for treatment discontinuation with Nexletol, affecting 0.4% of patients compared to 0.1% on placebo [1.2.1]. For those asking, **can Nexletol cause diarrhea?**, the data shows it is a recognized, though not highly common, side effect.

Approximately 32 million people in the U.S. take statins to manage cholesterol, but many wonder, **what is the safest cholesterol medicine with the least side effects?**. The answer is nuanced, as the ideal medication depends on individual health profiles, but certain medications are generally better tolerated, and a range of options exist for those with specific sensitivities.

A 2022 meta-analysis of over 4 million patients found the overall prevalence of statin intolerance to be 9.1% [1.6.2]. For these individuals and others needing more aggressive cholesterol management, the key question is: **What is the new alternative to statins?** Several innovative drugs now offer powerful solutions.

In a study of over 25,000 middle-aged adults with no known heart disease, over 42% were found to have atherosclerosis (plaque buildup) [1.8.4]. So, what drug removes plaque from arteries and how can this condition be managed?

In the landmark CLEAR Outcomes trial, which followed nearly 14,000 patients, bempedoic acid (the active ingredient in Nexletol) was found to be generally safe and well-tolerated, demonstrating a good benefit-to-risk ratio. As an alternative treatment for high cholesterol, understanding **how safe is Nexletol** is crucial for patients, especially those who cannot tolerate statins due to their side effects.

In the United States, nearly 28% of adults aged 40 to 59 have high cholesterol [1.10.1]. For those needing non-statin options, the question 'Which is better, Nexletol or Zetia?' is a critical one. Both medications offer unique pathways to lowering LDL cholesterol, but their suitability depends on individual patient factors.