What is the newest and best antidepressant? Unpacking the Latest Treatments
•
4 min read
In 2025, the U.S. Food and Drug Administration (FDA) expanded the approval for Spravato (esketamine), making it a new standalone monotherapy option for adults with treatment-resistant depression. There is no single answer to "what is the newest and best antidepressant?" because the most effective treatment depends on individual patient factors. Several novel medications have recently hit the market, targeting different mechanisms than traditional antidepressants.
