Tag: Beyond use date

A key factor in determining how long a 5ml vial of semaglutide will last for most compounded versions is the 28-day beyond-use date after the first puncture, rather than solely the total volume. This stability period, alongside the medication's concentration and prescribed administration schedule, dictates the practical lifespan of the vial.

A needle puncture introduces a risk of microbial contamination into a multi-dose medication vial, which is why regulatory bodies like the Joint Commission enforce the **28 day puncture rule**. This critical guideline helps ensure patient safety by preventing the use of potentially contaminated injectable drugs.