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Tag: Bh3 mimetic

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What is the mechanism of action of Obatoclax?: Unraveling its Multifaceted Cellular Effects

3 min read
Overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of many cancers, making them an attractive target for novel therapies. The investigational anti-cancer agent Obatoclax is a BH3 mimetic designed to inhibit these pro-survival proteins. So, what is the mechanism of action of Obatoclax? Its effects are multifaceted and extend beyond simple apoptosis inhibition.