Tag: Cannabis tolerance

According to research, cannabinoid (CB1) receptors can begin to re-sensitize after just 48 hours of abstinence from cannabis. This rapid re-sensitization means that even a short break can help lower your tolerance, but the ideal length for a successful and lasting reset depends on your usage habits and individual biology, a key consideration when asking, "How long should my T break be for edibles?".

The effects of cannabis edibles can take anywhere from 30 minutes to two hours to appear, a delay caused by the body's digestive and metabolic processes [1.2.1, 1.6.2]. This article explores the pharmacological reasons behind how to know if edibles don't work for you, from genetics to tolerance.

According to studies, as many as one in four people possess genetic variants that can lead to slower THC metabolism, significantly altering how cannabis is processed. If you've ever asked, 'Why do edibles not kick in for me?', you're not alone, and the answer often lies in a complex interplay of personal biology and pharmacology.