Tag: Carcinogenicity

Beta-asarone is a primary active component found in the essential oil of plants like *Acorus calamus*, where its concentration in some varieties can be as high as 95% [1.5.1]. This article delves into what are the properties of beta asarone, covering its dual nature of therapeutic potential and toxicity.

An estimated 8 million U.S. healthcare workers are potentially exposed to hazardous drugs annually [1.5.1, 1.5.2, 1.5.5]. This significant risk raises a critical question for workplace safety: **what makes a drug considered hazardous** and necessitates stringent handling protocols?

According to extensive safety assessments from organizations like the Cosmetic Ingredient Review (CIR) Expert Panel and the FDA, there is no evidence to suggest that tromethamine is carcinogenic. These reviews, covering both cosmetic and pharmaceutical uses, have consistently found the compound to be safe when used as directed.

Introduced in the 1950s for hypertension and psychiatric conditions, reserpine was one of the first modern antihypertensive drugs, but its use declined precipitously due to serious side effects. Understanding why is reserpine banned reveals the evolution of pharmacology and medication safety standards.

Contrary to a common misconception, permethrin is not banned in the USA and remains a widely used insecticide and pharmaceutical. Its status is instead governed by strict federal regulations designed to manage potential risks associated with high concentrations and environmental impact.

According to the Globally Harmonized System (GHS) of classification, a substance can be designated as a **Category 1B toxicity**, which means there is strong evidence from animal studies suggesting a potential hazard to human health. This designation plays a critical role in drug development, handling protocols, and patient safety.

While some animal studies using high doses of fenofibrate showed an increased incidence of liver and pancreatic carcinomas, a meta-analysis of 17 human randomized controlled trials (RCTs) involving 44,929 participants found that fibrate therapy had a neutral effect on cancer incidence and mortality [1.3.5, 1.5.6]. The question of 'Is fenofibrate carcinogenic?' remains complex, with significant differences between rodent and human responses.

According to the National Institute for Occupational Safety and Health (NIOSH), spironolactone has been included on its list of hazardous drugs for several years. This classification is not due to patient risk during normal use, but rather because of the occupational risk to healthcare workers who handle and prepare it, which is why spironolactone is considered a hazardous drug.