Tag: Cardiac toxicity

Overdosing on excessive calcium channel blockers (CCBs) is considered one of the most lethal prescription drug overdoses. This makes recognizing **what are signs of calcium channel blocker overdose?** a critical, life-saving skill. A severe overdose can quickly lead to shock, cardiac arrest, and death if not treated promptly.

According to the National Institutes of Health, bupivacaine possesses a lower cardiovascular collapse to central nervous system (CC:CNS) toxicity ratio than lidocaine, indicating a smaller safety margin for cardiac complications. This critical distinction is a direct result of fundamental differences in how each local anesthetic interacts with and affects cardiac tissue, defining why bupivacaine is more cardiotoxic than lidocaine.

According to medical experts, co-administering hydroxychloroquine and amitriptyline can significantly increase the risk of a serious, potentially life-threatening irregular heart rhythm, also known as QT prolongation. This combination requires careful consideration by a healthcare provider to ensure patient safety when managing conditions like lupus or rheumatoid arthritis alongside depression or neuropathic pain.

According to reports from the FDA and poison control centers, misuse and abuse of high doses of the antidiarrheal medicine loperamide, or Imodium, has been linked to serious heart problems and death. This article details the significant damage that can result from taking more than the recommended dosage, either intentionally or unintentionally.