Tag: Cardiovascular toxicity

Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication that occurs when local anesthetics enter the systemic circulation. For healthcare providers and patients alike, recognizing what are the early signs of local anesthetic toxicity is critical for preventing a medical emergency.

According to a study reported by the National Institutes of Health, epinephrine overdose resulting from medical errors is a known cause of adverse outcomes, underscoring the critical importance of proper dosage. Knowing what happens if you inject too much adrenaline is vital for understanding the risks involved, especially in emergency situations where epinephrine auto-injectors (like EpiPens) are used.

Recent data suggests the incidence of Local Anesthetic Systemic Toxicity (LAST) is approximately 1 to 2 cases per 1,000 peripheral nerve blocks [1.7.1, 1.7.6]. Knowing **what are the symptoms of LA toxicity** is crucial for rapid identification and management of this life-threatening event.