Tag: Cb1 receptor

The endocannabinoid system, a key regulator of appetite and metabolism, involves cannabinoid 1 (CB1) receptors located in the brain and periphery. A **cannabinoid 1 receptor antagonist** is a medication that blocks these receptors to inhibit their activity, offering a potential therapeutic avenue for conditions like obesity and addiction.

Research using positron emission tomography (PET) has demonstrated that chronic daily cannabis smokers experience a reversible downregulation of cannabinoid CB1 receptors. The question of **how long does it take for cannabinoid receptors to return to normal** is crucial for understanding the science behind cannabis tolerance and withdrawal.

According to a 2019 study, the cannabinoid THCP (tetrahydrocannabiphorol) has up to 33 times more binding affinity for the brain's CB1 receptors than Delta-9 THC [1.2.1]. This fact raises the critical question for many: **Is delta 9 or THCP stronger?**