Is CBD a COX-2 inhibitor? Understanding Cannabidiol's Anti-Inflammatory Mechanisms
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4 min read
While cannabidiol (CBD) is not a direct cyclooxygenase-2 (COX-2) inhibitor like many common non-steroidal anti-inflammatory drugs (NSAIDs), its raw, unheated precursor, cannabidiolic acid (CBDA), has been shown in studies to selectively inhibit the COX-2 enzyme. This distinction is critical for understanding the different anti-inflammatory mechanisms of cannabis compounds.
