Tag: Cell biology

First introduced into clinical ophthalmology in Japan in 2014, a **rock inhibitor** is a class of compounds that targets the Rho/ROCK signaling pathway, a crucial regulator of cellular functions like migration, adhesion, and contraction. This innovative pharmacological approach has broad therapeutic potential by interfering with fundamental cell signaling processes.

First identified in the Simian Virus 40 (SV40) large T-antigen, the nls peptide is a short amino acid sequence that functions as a critical cellular postal code, directing proteins and other molecules from the cytoplasm into the cell's nucleus. This active transport process is essential for many fundamental cellular processes, including DNA replication, transcription, and gene expression.