Tag: Cholinergic system

Neostigmine, first patented in 1931, is a classic anticholinesterase medication with a well-established role in clinical pharmacology. Its therapeutic effectiveness hinges on its core function as an inhibitor of the enzyme acetylcholinesterase, which provides the answer to what is the mechanism of action of neostigmine.

Discovered and characterized extensively since the 1970s, the nicotinic receptor is one of the most well-understood membrane receptors at a structural and functional level. These ligand-gated ion channels play critical roles in rapid neural and neuromuscular communication throughout the body.

Based on animal studies, the effect of ivermectin on dopamine levels appears to be complex and dose-dependent, with recent preclinical research suggesting that ivermectin increases dopamine release indirectly in certain brain regions, while older studies show inhibition. This complexity is crucial when considering the question: does ivermectin increase dopamine?