Tag: Chronopharmacology

According to the Centers for Disease Control and Prevention, nearly 70% of adults aged 65 and over take three or more prescription drugs in a given month. Learning **how to schedule medication times** is a critical skill for maximizing treatment benefits and ensuring consistency, especially with complex regimens.

Latanoprost can reduce intraocular pressure (IOP) by 22% to 39% [1.2.2]. Understanding why does latanoprost work better in the evening involves aligning the drug's peak effectiveness with the eye's natural circadian rhythms to manage glaucoma and ocular hypertension optimally [1.2.1, 1.4.2].

Over 25 million people in the U.S. have asthma, a condition where symptoms often worsen at night. The recommendation for *why should montelukast be taken at night* is rooted in the principles of chronopharmacology, aiming to align the drug's peak effectiveness with the body's natural rhythms.

As many as 75% of people with asthma report experiencing worsening symptoms during the nighttime. The primary reason for this is a circadian rhythm effect, which dictates why is montelukast taken at night to align with the body's natural inflammatory cycle for maximum therapeutic benefit.

Intraocular pressure (IOP) follows a natural circadian rhythm, often rising during nocturnal hours while the body is in a horizontal position. Because its primary mechanism of action is to suppress the production of aqueous humor, this rhythm, coupled with other physiological changes during sleep, is precisely **why is timolol not effective at night**.

The 2017 Nobel Prize in Physiology or Medicine recognized the fundamental importance of biological clock function, a concept that forms the bedrock of chronopharmacology. Chronopharmacology is the study of how the timing of drug administration influences its effects, effectiveness, and toxicity within the body's natural rhythms. This field emphasizes that medications are not equally effective at all hours of the day.