Tag: Cirrhosis

Reports indicate that methadone can be used in patients across different stages of chronic liver disease, including cirrhosis, without worsening the underlying condition. This does not mean, however, that the medication is without risk, especially regarding how its metabolism is affected when liver function is impaired. So, **is methadone contraindicated in liver disease?** The answer is complex and depends heavily on the severity of the hepatic impairment.

According to a 2020 study of heart failure patients, higher doses of spironolactone (50-100 mg) were independently associated with hyponatremia. This highlights the critical question: Can spironolactone cause hyponatremia, and if so, what are the underlying mechanisms and management strategies?

According to extensive meta-analysis, non-selective beta-blockers like propranolol can reduce the risk of a first variceal bleeding episode by about 50% in high-risk patients. This remarkable efficacy demonstrates **why propranolol helps with varices** by addressing the underlying cause of high pressure in the portal venous system.

With a sustained virologic response (SVR) rate exceeding 95% in many cases, Harvoni has revolutionized Hepatitis C treatment. While the medication is highly effective and generally well-tolerated during treatment, understanding **what are the long-term side effects of taking Harvoni** is crucial for patients with pre-existing liver damage or co-existing conditions.

An estimated 4.5 million adults in the United States have been diagnosed with liver disease [1.11.1, 1.11.2]. The term 'hepatic' refers to the liver, so the question 'What is hepatic used for?' explores the pharmacology of medications that treat liver conditions [1.2.1, 1.2.2].

Harvoni, a combination of the direct-acting antivirals ledipasvir and sofosbuvir, can be given for a duration of 8 to 24 weeks, depending on the patient's specific health profile. This advanced medication revolutionized hepatitis C treatment by offering high cure rates with a once-daily, single-tablet regimen.

The World Health Organization estimated that 254 million people were living with chronic hepatitis B (HBV) in 2022, a condition that can lead to severe liver damage [1.6.2]. A key question for patients is: **can tenofovir reverse liver damage** caused by this virus?