Tag: Clostridium perfringens

While cefepime is a powerful antibiotic effective against many aerobic pathogens, its coverage against anaerobic bacteria like *Clostridium perfringens* is limited or non-existent. In fact, guidelines often recommend adding a separate antibiotic with reliable anaerobic activity when treating polymicrobial infections where anaerobes are a concern.

Clostridium perfringens is a significant cause of foodborne illness in the U.S., responsible for an estimated one million cases each year [1.11.1, 1.11.3]. For severe soft tissue infections like gas gangrene, knowing what is the first line of treatment for Clostridium perfringens—typically a combination of antibiotics and surgery—is critical [1.2.1, 1.3.2].

In severe *Clostridium perfringens* infections like gas gangrene, mortality rates can be significant, highlighting the urgent need for effective treatment. Finding the best antibiotic for *Clostridium perfringens* is crucial and typically involves a combination approach to combat both bacterial proliferation and toxin production.