Tag: Clozapine side effects

While most people associate the antipsychotic medication clozapine with severe constipation, diarrhea is a recognized, albeit less common, adverse effect. Case studies indicate that **clozapine** can **cause** gastrointestinal issues, including colitis, which can manifest as diarrhea, particularly in the initial weeks of treatment.

Approximately 20% to 33% of people with schizophrenia have treatment-resistant schizophrenia (TRS), for whom clozapine is often the most effective medication [1.9.1]. Understanding what interferes with clozapine is critical for its safe and effective use, as numerous substances can alter its levels in the body [1.2.1, 1.3.1].

According to prescribing information and clinical observations, heartburn is a reported side effect of the antipsychotic medication clozapine. This gastrointestinal issue, along with others like constipation and nausea, is caused by the drug's effects on the digestive system. Understanding why and how **clozapine causes heartburn** is crucial for patients and healthcare providers to manage this potentially uncomfortable symptom effectively.