Tag: Cns infection

Tuberculous meningitis (TB meningitis) is a devastating infection with high mortality and neurological disability rates, partly because standard doses of rifampin exhibit poor penetration across the blood-brain barrier (BBB), leading to subtherapeutic concentrations in the central nervous system (CNS).

Bacterial meningitis is a medical emergency requiring immediate, aggressive treatment to prevent severe complications and death. A critical question during diagnosis is, **Does oral amoxicillin treat meningitis?** The definitive answer is no, and relying on it can be fatal.

The blood-brain barrier (BBB) is a highly selective semipermeable border that protects the central nervous system (CNS) from circulating pathogens and chemicals. While typically restrictive, the answer to **does amoxicillin cross the brain barrier?** is complex and context-dependent, relying heavily on the presence of meningeal inflammation.