Tag: Cns toxicity

Systemic toxicity is the most significant adverse effect of lidocaine, a common local anesthetic, and it can affect the central nervous system and heart. While many side effects are mild and localized, severe complications can occur if the medication is absorbed into the bloodstream in large amounts, particularly from injections or overuse of topical forms.

Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication that occurs when local anesthetics enter the systemic circulation. For healthcare providers and patients alike, recognizing what are the early signs of local anesthetic toxicity is critical for preventing a medical emergency.

Up to 30% of patients experience side effects when taking cycloserine, a second-line antibiotic for tuberculosis [1.2.2]. Understanding 'What are the contraindications for cycloserine?' is crucial for patient safety and effective treatment outcomes.

Valacyclovir is a widely used antiviral, but in rare cases, particularly among individuals with renal dysfunction, it can cause neurotoxicity. Understanding how does valacyclovir affect the brain is critical for recognizing potential side effects and mitigating risks, especially in vulnerable populations.

Recent data suggests the incidence of Local Anesthetic Systemic Toxicity (LAST) is approximately 1 to 2 cases per 1,000 peripheral nerve blocks [1.7.1, 1.7.6]. Knowing **what are the symptoms of LA toxicity** is crucial for rapid identification and management of this life-threatening event.

Up to 30% of patients experience side effects when taking cycloserine [1.4.4]. Knowing **which condition is adverse to cycloserine** is critical for patient safety, especially for those with pre-existing neurological, psychiatric, or renal issues [1.2.3, 1.3.4].