Tag: Coagulation factors

According to studies, uncontrolled hemorrhage accounts for 30%–45% of all trauma-related deaths. This statistic underscores the critical importance of effective hemostatic therapy, which involves a range of medications and blood products that control severe bleeding. These drugs are essential in managing major hemorrhage, particularly in trauma, surgery, and obstetric emergencies, where rapid action is necessary to prevent fatality.

Prothrombin complex concentrate (PCC) is an emergency medication that can reverse the effects of certain blood thinners in minutes, a speed far greater than alternatives like fresh frozen plasma. This rapid action is thanks to its unique and concentrated composition, but exactly what is PCC composed of?

Did you know that modern Prothrombin Complex Concentrate (PCC) is derived from large pools of human plasma and undergoes rigorous viral inactivation to ensure safety? This potent medication is critical in emergency medicine, as it contains essential coagulation factors that are used to quickly reverse the effects of certain anticoagulants and address severe bleeding disorders.

FEIBA is a sterile, freeze-dried human plasma fraction manufactured from large pools of human plasma. This article delves into the key question: what is FEIBA made of and how do its components work to control bleeding in patients with hemophilia and inhibitors?

In clinical trials, Feiba was effective in managing 88% to 93% of bleeding episodes in patients with hemophilia and inhibitors. **What is Feiba?** It is an Anti-Inhibitor Coagulant Complex used to control and prevent bleeding in these specific patient populations.