Tag: Codeine interactions

In 2021, nearly 14% of overdose deaths involving opioids also involved benzodiazepines, highlighting the severe risks of mixing medications [1.5.2]. Understanding what cannot be mixed with codeine is critical for preventing life-threatening interactions and ensuring patient safety.

According to the FDA, the concurrent use of opioids like codeine with other Central Nervous System (CNS) depressants significantly increases the risk of severe respiratory depression, sedation, and death. Understanding what not to mix with Tylenol with codeine is a crucial step in preventing these life-threatening complications and ensuring your medication is used safely.