Tag: Colchicine toxicity

For patients taking colchicine, gastrointestinal side effects, particularly diarrhea, are common, affecting over 20% in some studies, and often linked to dosage. This article explores why does colchicine cause diarrhea, its mechanism, and management strategies to help patients cope with this potential complication.

Colchicine is an ancient anti-inflammatory drug with a narrow therapeutic index, meaning the difference between a therapeutic dose and a toxic dose is very small. This potent and potentially hazardous medication must be handled with extreme care, which is why you can't touch colchicine directly, especially in its powdered or uncontained forms.