Tag: Coleus forskohlii

A 2019 study published in *Nutrients* revealed that among users of *Coleus forskohlii* extract, 10.5% reported experiencing adverse events, primarily gastrointestinal symptoms like diarrhea. This highlights the importance of understanding what are the negative effects of forskolin before using the supplement.

Originally used in Ayurvedic medicine for centuries, the compound known as forskolin has a primary pharmacological effect rooted deeply in cellular signaling, specifically by activating the enzyme adenylate cyclase. This unique action elevates cyclic adenosine monophosphate (cAMP) within cells, influencing a wide range of bodily functions, including metabolism, cardiovascular health, and respiratory function.

In mice studies, while crude *Coleus forskohlii* extract has been shown to induce fatty liver and hepatotoxicity, the isolated compound forskolin was not responsible for these adverse effects, highlighting a critical distinction for liver health.