Tag: Combined androgen blockade

While both Zoladex and Casodex are used in the hormonal treatment of advanced prostate cancer, a key distinction lies in their mechanisms of action: Zoladex (goserelin) is an LHRH agonist that suppresses the body's testosterone production, whereas Casodex (bicalutamide) is an antiandrogen that blocks testosterone's ability to stimulate cancer growth. This difference means they are not interchangeable and are often used together in a treatment strategy known as Combined Androgen Blockade.

Over 80% of prostate cancer cases are sensitive to hormonal therapy, which often involves a specific sequencing of medications. A key part of this regimen is understanding when to start Zoladex after bicalutamide to manage the initial hormonal response and avoid complications like tumour flare.

The American Cancer Society estimates there will be about 313,780 new cases of prostate cancer in the United States in 2025 [1.6.2]. A primary treatment involves asking: **Can Zoladex and Casodex be taken together?** Yes, this combination is a standard approach.