Tag: Contraction alkalosis

Diuretic therapy is a very common cause of metabolic alkalosis encountered in clinical practice. This article explains the complex physiological mechanisms behind why **do thiazide diuretics cause contraction alkalosis**, a key metabolic side effect associated with their long-term use.

Contrary to a common misconception, loop diuretics do not cause metabolic acidosis; instead, they are a frequent cause of metabolic alkalosis. The mechanism involves a complex interplay of fluid loss, hormonal changes, and electrolyte imbalances within the kidneys.

According to research, metabolic alkalosis is one of the most common acid-base disorders in patients with congestive heart failure, most often resulting from diuretic therapy. This occurs due to several factors involving the kidneys' complex acid-base and electrolyte handling. Understanding these mechanisms is crucial for managing diuretic therapy and its potential complications.