Is Aspirin a Covalent Inhibitor? Understanding Its Irreversible Action
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3 min read
Aspirin is one of the oldest and most common anti-inflammatory agents, with evidence pointing to its use for over a century. Unlike many non-steroidal anti-inflammatory drugs (NSAIDs), its key pharmacological effect depends on a permanent bond, making many question: is aspirin a covalent inhibitor? The answer lies in its unique irreversible mechanism.