Tag: Cox 1 inhibition

In a study of older adults, daily low-dose aspirin was found to increase the overall risk of major gastrointestinal bleeding by 60% compared to a placebo [1.8.4]. Understanding **why does aspirin cause stomach issues** is crucial for anyone taking this common medication, as the effects go beyond simple irritation.

Over 70% of aspirin's irreversible inhibition of platelet function happens in the portal circulation, before the drug enters systemic circulation. This unique mechanism is the key to understanding what does aspirin do to platelets, primarily by blocking an enzyme crucial for the clotting process.