Tag: Cox 3

While aspirin's mechanism of action involving COX-1 and COX-2 has been understood for decades, the question of **does aspirin inhibit COX-3** is far more complex and debated in the scientific community. The discovery of a potential COX-3 isoform in the early 2000s initially suggested a central analgesic target, but subsequent research has introduced significant uncertainty.

Acetaminophen is among the drugs believed to inhibit the cyclooxygenase-3 (COX-3) enzyme, a variant first discovered in canine brain tissue in 2002. This discovery sparked significant interest because it offered a potential explanation for the central, or brain-based, analgesic and antipyretic actions of certain medications, particularly the question of which drug inhibits COX-3 without causing significant peripheral side effects. However, the role and functional significance of COX-3 in humans remain a subject of debate within the scientific community.