Tag: Cox inhibitors

The British pharmacologist Sir John Vane's discovery in 1971 revealed that aspirin primarily works by inhibiting the cyclooxygenase (COX) enzyme, a breakthrough that earned him a Nobel Prize. This irreversible inhibition is the foundational answer to the question: **Which mechanism of action is true of aspirin?** and explains its wide-ranging therapeutic effects.

A 2020 study using a mouse model with genetically enhanced inflammation showed that ibuprofen treatment reduced neuroinflammation and resulted in significant improvements in cognitive function. This suggests potential, but also complexity, when exploring how and if **will ibuprofen reduce brain inflammation** in humans.

An estimated 30 million people use nonsteroidal anti-inflammatory drugs (NSAIDs) every day across the globe [1.6.1, 1.6.5]. But a common question remains: **Is an NSAID a painkiller?** The short answer is yes, they are a specific type of painkiller with a dual function.

In the United States, an estimated 29 million people took aspirin in 2020. This common medication provides relief from inflammatory symptoms, but how does aspirin act to decrease the symptoms of inflammation? The answer lies in its ability to block key enzymes involved in the body's inflammatory response.