Tag: Csf production

First-line pharmacological treatment for idiopathic intracranial hypertension often includes acetazolamide, a medication widely used for its ability to reduce intracranial pressure. But **can acetazolamide decrease intracranial pressure** and how effective is it? The answer is a resounding yes, primarily by inhibiting the enzyme carbonic anhydrase in the brain's choroid plexus to reduce cerebrospinal fluid production.

According to the landmark Idiopathic Intracranial Hypertension Treatment Trial (IIHTT), a combination of acetazolamide and a low-sodium weight-reduction diet resulted in modestly significant visual field improvements for patients with mild visual loss. This makes acetazolamide a cornerstone of medical therapy for IIH.