Tag: Ctcae

According to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE), over a thousand different adverse events are graded on a severity scale from 1 to 5. The mildest of these is grade 1 toxicity, representing asymptomatic or mild symptoms that do not require significant medical intervention.

In clinical trials, a Grade 4 toxicity represents a life-threatening adverse event where urgent intervention is required [1.2.1, 1.3.2]. Understanding this classification is crucial for evaluating drug safety. So, what is a grade 4 toxicity and how is it managed?