What CYP Enzyme Metabolizes Ibuprofen? Understanding Pharmacogenomics
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4 min read
Ibuprofen is primarily metabolized by the cytochrome P450 (CYP) enzymes CYP2C9 and CYP2C8, a fact critical to understanding its pharmacology and potential side effects. For example, studies show that genetic variations in the CYP2C9 enzyme can significantly impact how quickly individuals process ibuprofen, influencing drug efficacy and the risk of adverse reactions. This intricate metabolic process in the liver is a cornerstone of a field known as pharmacogenomics, which explains why a standard dose of medication can have different effects from person to person.
