Tag: Cyp2d6 inhibition

According to the National Institutes of Health, bupropion inhibits the metabolism of dextromethorphan by inhibiting the CYP2D6 enzyme, leading to increased blood levels of dextromethorphan. This critical pharmacological interaction explains why you must be extremely cautious about whether Robitussin can be taken with Wellbutrin, as mixing these common medications can lead to dangerous side effects.

According to a study involving nursing home residents, taking certain antidepressants with opioids like codeine was linked to a higher rate of worsening pain. Therefore, caution is essential to determine if you can take codeine while on antidepressants, as significant drug interactions can occur, rendering the pain medication ineffective or increasing serious health risks.

While both DULoxetine and amitriptyline are used to manage conditions like chronic pain and depression, combining them is generally not recommended due to significant health risks. The potential for serious drug interactions, including the life-threatening condition known as serotonin syndrome, requires strict caution and medical oversight for this combination.

Studies have shown that duloxetine, the active ingredient in Cymbalta, can significantly increase the blood levels of metoprolol by inhibiting its metabolic pathway. This interaction means that while it is possible for a doctor to prescribe both medications, careful monitoring and potential dose adjustments are necessary to ensure the safety of anyone who takes metoprolol and Cymbalta together.