Tag: Cyp2e1

While most of a therapeutic dose of acetaminophen is safely eliminated from the body, approximately 5% to 10% is metabolized by cytochrome P450 (CYP) enzymes into a toxic byproduct called N-acetyl-p-benzoquinone imine (NAPQI). The primary enzyme responsible for this process is CYP2E1, though other CYP enzymes also play a role, especially at higher doses. Understanding which CYP metabolizes acetaminophen is crucial for comprehending the risks of drug-induced liver injury.

While the alcohol dehydrogenase (ADH) enzyme is the primary catalyst for ethanol metabolism, research confirms that yes, **CYP450** enzymes do play a significant role in helping **break down alcohol**, especially in cases of heavy or chronic consumption. This secondary pathway, known as the Microsomal Ethanol-Oxidizing System (MEOS), relies heavily on the specific enzyme CYP2E1.