Tag: Dao

Over 1% of the population may suffer from histamine intolerance, a condition caused by a lack of the enzyme diamine oxidase (DAO), not an excess. The idea of "too much DAO" is a common misconception, as side effects and symptoms are not linked to high natural enzyme levels but rather to issues like DAO supplements or underlying medical conditions.

It's estimated that up to 20% of the population takes a medication that can decrease diamine oxidase (DAO) activity, the enzyme responsible for breaking down histamine. This makes understanding what medications make histamine intolerance worse a critical part of symptom management. This pharmacological guide will outline the key drug classes to be aware of and how they can interfere with histamine metabolism.