Tag: Deplin

While Deplin is a prescription-only medical food, its active ingredient, L-methylfolate, is widely available over the counter (OTC) as a dietary supplement. Many individuals seek these OTC options as a more affordable or accessible alternative, particularly since health insurance often does not cover the high cost of Deplin.

In clinical trials, some individuals noticed improvements in symptoms with Deplin in as little as 30 days, though the full effect often takes longer. The answer to how long should I take Deplin? is not a one-size-fits-all, but rather a decision made collaboratively with your healthcare provider.

Up to 70% of people with depression may have a genetic variation (MTHFR) that compromises their body's ability to process folate into its active form, L-methylfolate. This raises the critical question for many: **Does Deplin really work** as a targeted nutritional therapy to overcome this deficiency and improve treatment outcomes?