Tag: Dermatological effects

Adverse skin reactions are among the most common side effects associated with psychotropic drugs, including the tricyclic antidepressant amitriptyline. The effects of amitriptyline on the skin can range from mild irritations like rashes and hives to more serious conditions like photosensitivity and hypersensitivity syndrome. Patients and healthcare providers must be aware of these potential dermatological manifestations to ensure safe medication use.

According to reports, millions of Americans have used kratom, a substance derived from the *Mitragyna speciosa* tree. A rare but increasingly recognized cutaneous side effect associated with chronic, long-term kratom use is hyperpigmentation, a skin discoloration that can manifest as brown, gray, or blue-gray patches. These effects, documented in numerous case reports, highlight a potentially serious dermatological consequence of the unregulated substance.