Tag: Desacetylcefotaxime

Approximately 60% of an administered dose of cefotaxime is excreted unchanged by the kidneys. This fact makes proper dosing in patients with kidney disease a critical safety concern. So, **does cefotaxime need renal adjustment?** Yes, particularly in severe impairment.

Approximately 50% to 60% of an administered dose of cefotaxime is excreted unchanged by the kidneys [1.3.3, 1.5.1]. Understanding the clearance of cefotaxime is crucial for ensuring its efficacy and safety, as this process dictates how quickly the drug is removed from the body.