Tag: Dili

In 2024, a medical journal documented the first histologically confirmed case of severe drug-induced liver injury (DILI) in a patient who self-administered fenbendazole. This and other reports underscore the critical question: **Can fenbendazole cause liver damage in humans?** Despite being marketed exclusively for animal use, its off-label consumption is a documented and dangerous phenomenon.

Losartan is a widely prescribed angiotensin II receptor blocker for hypertension, with a reported incidence of minor liver enzyme elevations of less than 2% during clinical trials. While generally considered safe, the potential for drug-induced hepatotoxicity is a rare but documented risk, leading many to ask: **Can losartan raise ALT levels?**

Drug-Induced Liver Injury (DILI) is a leading cause of acute liver failure in the United States and a major reason for drug withdrawal from the market. The liver, a primary site for drug metabolism, is particularly susceptible to damage from various medications, which directly answers the question, 'Does ADRs affect the liver?'.

According to the National Institutes of Health (NIH), antibiotics are the most common cause of drug-induced liver injury (DILI), accounting for 45% of cases. This can cause concern for many patients, prompting the question: which antibiotic is not good for the liver? The answer is not a single drug, but rather a class of medications that carry varying levels of risk for hepatotoxicity.

Adverse drug reactions (ADRs) account for an estimated 6.5% of hospital admissions in the United Kingdom [1.2.5]. A small but significant portion of these are due to a phenomenon known as **what is idiosyncratic toxicity?**: a severe, unpredictable reaction that occurs in a small subset of individuals taking a specific drug [1.2.1, 1.2.5].

In the United States, acetaminophen toxicity is responsible for approximately 50% of all acute liver failure cases [1.3.1]. While widely used, understanding **what is the most common drug that can cause liver damage** is crucial for preventing unintentional harm.