Tag: Disease flare

For patients taking corticosteroids for chronic inflammatory conditions, studies show that a recurrence of symptoms, or a flare-up, is a distinct possibility after stopping prednisone. This is not simply a side effect, but often a sign that the underlying disease process has become active again.

According to the Arthritis Foundation, approximately 90% of rheumatoid arthritis (RA) patients use methotrexate at some point in their treatment. Knowing how do you wean off of methotrexate is a crucial step for many patients, whether due to achieving remission, experiencing intolerable side effects, or planning for pregnancy.

According to a 2019 study, rheumatoid arthritis patients who underwent immediate tofacitinib withdrawal had a flare-free survival time significantly shorter than those who gradually reduced their dose. This highlights the significant risk of a disease flare when you stop tofacitinib without medical supervision, which can cause the return of painful symptoms and potentially lead to disease progression.

In one study of long-term methotrexate users in remission, over 40% experienced a disease flare within six months of discontinuation. For patients on long-term treatment for conditions like rheumatoid arthritis, the question, **Can you ever get off of methotrexate?**, is complex and requires careful consideration with a healthcare provider.

According to one study, discontinuing hydroxychloroquine (Plaquenil) in lupus patients was linked to a 61% greater likelihood of experiencing a disease flare-up sooner than those who continued their medication. Therefore, understanding what happens when you stop Plaquenil is crucial, as the risks can significantly impact the long-term management of your autoimmune condition.