Tag: Dopamine supersensitivity

Approximately 20-30% of people with schizophrenia or related disorders experience what is known as treatment-resistant schizophrenia (TRS), indicating that it is indeed possible for a patient’s condition to become resistant to antipsychotics. This phenomenon is complex, involving various potential factors beyond simply building a tolerance to the medication.

While antipsychotics are a foundational treatment for psychosis, a growing body of evidence suggests a paradoxical effect may occur, particularly with long-term use. This phenomenon, known as dopamine supersensitivity psychosis (DSP), challenges the conventional understanding of these medications.