Tag: Dose response curve

An estimated 90% of drug candidates that enter clinical trials ultimately fail [1.8.2]. To improve success rates, researchers rely on key metrics like the half-maximal inhibitory concentration (IC50). So, what is the interpretation of IC50 values, and how does it guide drug discovery?

According to pharmacological principles, a drug is considered more potent than another if it produces the same effect at a lower concentration. Understanding how to tell which drug is most potent is critical in drug development and helps clinicians determine appropriate dosing for optimal patient care. It is a foundational concept that, while sometimes confused with efficacy, dictates the dose required to produce a desired effect.

In chronic toxicity testing, the IC25 is a critical statistical calculation used to determine the concentration of a substance that causes a 25% reduction in a biological function like growth or reproduction [1.2.1, 1.2.2]. Understanding **what is IC25 toxicity** is fundamental in pharmacology and environmental science for assessing the subtle, long-term effects of chemicals.