Tag: Dothiepin

Yes, dothiepin and Prothiaden are in fact the same medication, with Prothiaden being a common brand name for the active ingredient dothiepin. This is a common occurrence in pharmacology where the same drug is sold under different names depending on the manufacturer and the region where it is marketed.

Dothiepin, also known by its generic name dosulepin, is a tricyclic antidepressant (TCA) historically used in the treatment of major depressive disorder. Despite its documented effectiveness, its use has declined dramatically due to significant safety concerns, particularly its high toxicity in overdose.

While both amitriptyline and dosulepin are tricyclic antidepressants (TCAs) with similar mechanisms, a key distinguishing factor is their safety profile, particularly in overdose. Dosulepin is significantly more toxic in overdose compared to amitriptyline.